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MSK-2001

MSK-2001 is an investigational auto-injector of a single unit dose of epinephrine. It is intended for the treatment of life-threatening allergic reactions, also known as anaphylaxis. The allergic reaction may be triggered by a particular food, insect sting, pet dander, latex, medicine, exercise, or an unknown cause. For people at risk of a severe allergic reaction, MSK-2001 would be carried with them at all times for emergency administration. When they begin to manifest the signs and symptoms of a life-threatening allergic reaction, the auto-injector device would be place on the outer part of the thigh and a single dose of epinephrine would be injected. In some cases, administration of a second auto-injection would be needed. Emergency medical care should be sought immediately afterwards.

Currently, the available FDA-approved epinephrine auto-injectors have a limited shelf life of about a year, must avoid exposure to light, and must be kept within 59 and 89 degrees Fahrenheit. MSK-2001's proprietary formulation of epinephrine for auto-injection preserves the efficacious dose of epinephrine over a greater range of storage conditions and for a longer period of time. MSK-2001 addresses a market that in 2012 was about $700 million and which grew about 76% from 2011 to 2012. Although physicians don't known why, the rate of food allergies among children appears to be increasing. It is further believed that just 7 percent of people at risk for severe allergic reactions carry an epinephrine auto-injector.